The study was conducted at Fuji Seal Vietnam Co., Ltd. to examine the exposure and health risks of workers working in the printing and ink phase area when exposed to solvent vapor through the respiratory apparatus Toluene, Methyl Ethyl Ketone, Ethyl Acetate, Isopropyl Acohol. The results show that: During the monitoring period from July to November 2016, the amount of solvent vapor in the printing area and ink phase is quite high, at the highest Toluene printing area, it was 2.63 times higher than the standard equal to the health risk HQ male is 2.61 and HQ female is 3.37; Ethyl Acetate exceeded the highest of 4.34 times equal to the male HQ risk ratio of 4.29 and female HQ equal to 5.53; MEK exceeds 8.43 times equal to the health risk HQ male is 8.36 and HQ female is 10.79; Isopropyl Acohol exceeds 8.4 times equal to the health risk HQ male is 8.33 and HQ female is 10.75; At the inking area, MEK exceeds 8.43 times equal to the health risk HQ male is 8.36 and HQ female is 10.79. From the calculated data - analysis, found that the health of workers working in the printing and inking areas had high risks, the ability of workers suffering from diseases such as he dache, dizziness, skin damage,... and especially respiratory failure.